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| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Patient-Centered Pharmacotherapy | 55% | - Development and Implementation of Therapeutic Plans
|
| Topic 2: System-Based Standards and Population-Based Pharmacotherapy | 20% | - Medication-Use Systems
|
| Topic 3: Drug Information and Evidence-Based Medicine | 25% | - Drug Information Resources
|
1. A 53-year-old man has been diagnosed with a deep vein thrombosis. Weight = 94kg and height
= 170 cm. Creatinine clearance F 60 mL/min, CBC results are within normal limits, and baseline INR = 0.9.
The pharmacotherapy specialist receives orders for warfarin 5 mg orally every evening and enoxaparin 80 mg subcutaneously every 12 hours. Which of the following is the best course of treatment?
A) Continue enoxaparin 80 mg every 12 hours.
B) Change enoxaparin to 80 mg every 24 hours.
C) Change enoxaparin to 140 mg every 24 hours.
D) Change enoxaparin to 100 mg every 24 hours.
2. Investigators studying the relative nephrotoxicity of two aminoglycosides selected their sample size to detect a reduction in toxicity of 10%. Which of the following is the power of this study if the probability of falsely rejecting the null hypothesis is 0.05 and the probability of falsely accepting the null hypothesis is 0.20?
A) 0.10
B) 0.05
C) 0.95
D) 0.80
3. A 65-year-old man with heart failure is currently receiving digoxin, lisinopril, furosemide, and carvedilol. He is in normal sinus rhythm and is hemodynamically stable. His left ventricular ejection fraction is 30%. Which of the following statements best describes the role of digoxin therapy in this patient?
A) It can be synergistic with carvedilol.
B) It can decrease the risk of hospitalization.
C) It can improve mortality.
D) It can be safely discontinued.
4. A 58-year-old man presents with symptoms of the common cold (nasal congestion, headaches, and dry Cough).
He purchased XYZ Cold formula (acetaminophen, pseudoephedrine, and dextromethorphan), but after reading the cautionary information on the package, he thought he should obtain his pharmacist's advice. He has hypertension and is taking hydrochlorothiazide daily. His office blood pressures range from 127-134/82-88 mm Hg, and he has no other medical problems.
Which of the following instructions are applicable to this patient regarding XYZ Cold formula?
A) XYZ Cold would be safe short term because he has well-controlled hypertension.
B) Although pseudoephedrine is safe to use, he should use an antihistamine instead to better control his symptoms.
C) He should avoid XYZ Cold because it significantly raises blood pressure.
D) He should substitute nasal cromolyn for the decongestant.
5. A 53-year-old patient is admitted to the hospital with diarrhea. He has been experiencing five unformed stools daily for 2 days. The patient had a previous admission 6 weeks ago for C.
difficile diarrhea, which was treated successfully with oral metronidazole. Stool tests are again positive for C. difficile toxin A.
On presentation, his vital signs are: BP 128/86 mm Hg, HR 75 bpm, RR 14 bpm, and T37.8°C.
WBC count shows 12,300 cells/ul (80% neutrophils-segs, 10% neutrophils-bands), serum creatinine 1.2 mg/dL, and albumin 3.4 g/dL. The patient has no evidence of colitis, toxic megacolon, or perforation on imaging studies of the abdomen.
What is the most appropriate treatment recommendation for this patient?
A) Vancomycin 125 mg orally four times daily plus metronidazole 500 mg three times daily intravenously
B) Metronidazole 500mg orally three times daily
C) Rifaximin 550mg orally three times daily
D) Vancomycin 125mg orally four times daily
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: D | Question # 3 Answer: B | Question # 4 Answer: A | Question # 5 Answer: B |
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